Human Sera
Cayman Chemical Forchlorfenuron 100mg
A building block has been used in the synthesis of carcinolytic compounds
Cayman Chemical 7-MethylxnthIn 100mg
A depsidone active against E. faecalis H. influenzae M. catarrhalis S. aureus and S. pneumoniae (MICs 8 32 1 128 and 64 Ug/ml respectively) inhibits PheRS isolated from P. aeruginosa (IC50 42 UM) inhibits OATP1B1 and OATP1B3 (Kis 0.08 and 1.84 UM respectively in CHO cells expressing the human transporters)
Cayman Chemical TrIacontnoIc AcId 100mg
A building block has been used in the synthesis of 13C6-labeled naphthalenes and polychlorinated biphenyls
Cayman Chemical CIcloprofen 100mg
A histamine H3 and H4 receptor agonist (Kis 0.3 and 2.7 nM respectively in radioligand binding assays) selective for histamine H3 and H4 receptors over H1 and H2 receptors when used at 100 UM as well as 5-HT3 (Ki 240 nM) reduces potassium-induced increases in histamine levels in isolated rat cerebral cortex slices (EC50 2.8 nM) increases scratching in mice (ED50 0.9 Umol)
Cayman Chemical Myrislignan 50mg
An internal standard for the quantification of myristic acid by GC- or LC-MS
Cayman Chemical Phellandrene 100mg
A nonpeptide NK3 antagonist (Ki 1 nM) selective for NK3 over NK1 and NK2 receptors (Kis 144 and 100000 nM respectively in CHO cells expressing recombinant human receptors) inhibits neurokinin B-induced calcium mobilization in HEK293 cells expressing human NK3 receptors (IC50 16.6 nM) inhibits senktide-induced contractions in isolated rabbit iris sphincter muscle (pD2 9.1) reduces senktide-induced head shakes and tail whips in mice from 5-20 mg/kg inhibits senktide-induced wet-dog shakes increases extracellular dopamine and norepinephrine in the medial prefrontal cortex and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs
Cayman Chemical DIhydroxyaceton PhosphATm 50mg
A sesquiterpene with diverse biological activities inhibits lipid peroxidation in rat hepatic microsomes (IC50 9.8 M) scavenges hydroxyl and DPPH radicals in cell-free assays inhibits LPS-induced nitric oxide production in RAW 264.7 cells (EC50 10.1 M) cytotoxic to RAW 264.7 cells (CC50s 29.8 and 30.8 M in the presence and absence respectively of LPS) cytotoxic to N2a neuroblastoma cells and primary rat neurons inhibits paracetamol-induced decreases in hepatic GSH in rats at 250 mg/kg
Cayman Chemical MapenterolhydrochlorIde 50mg
An analytical reference standard categorized as a tryptamine intended for research and forensic applications
Cayman Chemical 5a-ndrost-16-en-3a-ol 100mg
An internal standard for the quantification of meglutol by GC- or LC-MS
Cayman Chemical τ-FluvalInate 50mg
An AMPK activator (EC50 9 nM) selective for AMPK over a kinase panel at 10 UM as well as CYP3A4 and CYP2D6 (IC50s 50 UM) and PXR (EC50 30 UM) increases muscle and liver levels of phosphorylated ACC and reduces insulin resistance in DIO mice at 30 mg/kg inhibits hepatic fatty acid synthesis in db/db mice
Cayman Chemical LAzetIdIn2carboxylIc ACD 100mg
A chiral building block has been used in the synthesis of a chiral synthetic antibiotic intermediate as well as in the stereoselective synthesis of NK receptor antagonists
Cayman Chemical AtIpamezole 100mg
A 5-HT2 agonist stimulates increases in intracellular calcium levels in CHO-K1 cells expressing human 5-HT2A 5-HT2B and 5-HT2C (EC50s 447 0.9 and 32 nM respectively) selective for human 5-HT2A and 5-HT2C (Kis 32 and 1 nM respectively) over human 5-HT1A 5-HT1D 5-HT6 and 5-HT7 rat 5-HT1B and 5-HT3 and guinea pig 5-HT4 receptors (Kis ≥1995 nM) as well as adenosine A1 and A2 histamine H1-3 dopamine D1-5 a1- a2- and B1-adrenergic M1-5 muscarinic nicotinic kainate AMPA and - - and K-opioid receptors (IC50s 1000 nM) but does bind to B2-adrenergic receptors (IC50 251 nM) increases plasma levels of corticosterone oxytocin and prolactin in rats (ED50s 2.43 4.19 and 4.03 mg/kg respectively)
Cayman Chemical Beclomethason 50mg
An allosteric antagonist of PAR2 inhibits SLIGRL-induced calcium mobilization by wild-type and 10 mutant forms of PAR2 in a FLIPR assay (IC50s 23 and 12-780 nM respectively) selective for PAR2 over PAR4 and PAR1 (IC50s 50000 nM respectively in aBarrestin-2 recruitment assay) inhibits SLIGRL-induced phosphorylation of ERK in 1321N1 astrocytoma cells at 10 UM