Human Sera
Cayman Chemical RefametInIb 50mg
An allosteric, selective inhibitor of MEK1 and MEK2 (IC50s = 19 and 47 nM, respectively); blocks phosphorylation of ERK1/2 across several human cancer cell lines differing in tissue origin and BRAF mutational status (EC50s = 2.5-16 nM); orally available and active in human tumor xenograft models
Cayman Chemical 1OOctadecyl2Omethylsng 100mg
A metabolite of a phosphotidylinositol ether lipid analog known to target the pleckstrin homology domain of Akt and to induce apoptosis in cancer cell lines with high levels of endogenous Akt activity
Cayman Chemical CInobufagIn 50mg
A cardiotonic steroid that has diverse biological activities; inhibits Na+/K+-ATPase activity in guinea pig heart ventricular muscle homogenates at 0.3 μM; is cytotoxic to HCT116 cells in vitro (IC50s = <50 ng/ml at 48- and 72-hour time points) and induces apoptosis; reduces tumor growth in an HCT116 mouse xenograft model at 10 mg/kg; inhibits LPS-induced expression of MHC class II, CD80, and CD86 and release of IL-6, IL-8, TNF-α, and IL-10 in human monocyte-derived dendritic cells at 1 μg/ml; increases expression of hBD2 and hBD3 in dendritic cells; exhibits antinociceptive effects in mice
Cayman Chemical EnalaprIlathydrate 100mg
The active metabolite of the ACE inhibitor, enalapril; inhibits ACE activity with an IC50 value of 5.8 nM in vitro
Cayman Chemical GalactInolhydrate 100mg
An α-galactoside of inositol that serves as a galactosyl donor in the transglycosidase-catalyzed biosynthesis of the raffinose family; generated from myo-inositol and uridine diphosphate galactose in a galactosyltransferase-catalyzed reaction
Cayman Chemical Ppequaln 50mg
A partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay); potentiates muscle relaxant and hypnotic effects of diazepam in mice; increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity
Cayman Chemical MoxIfloxacInhydrochlorIde 50mg
A fluoroquinolone antibiotic; active against 390 clinical isolates of various bacteria (MIC90s = ≤0.25 UG/ml), as well as clinical isolates of methicillin-susceptible and -resistant S. aureus (MIC90s = 0.12 and 2 UG/ml, respectively); an inhibitor of E. coli DNA gyrase that is selective for DNA gyrase over E. coli topoisomerase IV (IC50s = 0.51 and 38.8 mg/L, respectively, in cell-free assays); prevents S. aureus- and P. aeruginosa-induced increases in BALF neutrophil infiltration and reduces S. aureus- and P. aeruginosa-induced increases in lung CXCL1 and IL-1β levels in mouse models of bacterial pneumonia at 100 mg/kg twice per day for two days; decreases the number of lung and spleen CFUs in a mouse model of systemic M. tuberculosis infection at 100 mg/kg
Cayman Chemical ClotrImazole 50mg
An imidazole antifungal; tightly binds sterol 14-α demethylase isoform B from A. fumigatus (KD = 103 nM) and disturbs the fungal cell membrane; inhibits the calcium-dependent potassium channels Kv1.3 and IK-1 (IC50 = 6.0 and 0.07 µM, respectively) in mammalian cells
Cayman Chemical DutasterIde 100mg
An inhibitor of steroid 5α-reductase types I and II (Kis = 6 and 7 nM, respectively); a time-dependent inhibitor with apparent Ki values of 17 and 4.3 nM at 10- and 30-minute reaction times, respectively; decreases prostate weight in a rat model of benign prostatic hypertrophy induced by testosterone at 0.045 and 0.756 mg/kg administered as a solution or in subcutaneous microspheres, respectively, daily for 28 days; also decreases prostate weight in a transgenic model of prostate cancer
Cayman Chemical RValerolacton 100mg
An isomer of GVL, which is a prodrug to GHV; has potential for use as a biofuel
Cayman Chemical TInptInsodIum salt 100mg
An atypical antidepressant; an agonist of MORs (EC50s = 194 and 641 nM for human and mouse receptors in a BRET assay for G protein activation; decreases immobility in the forced swim test in wild-type, but not MOR knockout mice at 30 mg/kg; increases locomotor activity at a dose of 30, but not 10 mg/kg, in the open field test; prevents increases in chronic restraint stress-induced GLT-1 expression in the rat hippocampal CA3 region at 10 mg/kg per day for 21 days
Cayman Chemical FIdaxomycIn 50mg
A natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC50s = 0.4 and 6 μM, respectively); has potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive C. difficile (MIC = 12 ng/ml)
Cayman Chemical EnalaprIlathydrate 50mg
The active metabolite of the ACE inhibitor, enalapril; inhibits ACE activity with an IC50 value of 5.8 nM in vitro
Cayman Chemical TrofosfamIde 50mg
A nitrogen mustard alkylating agent and a derivative of cyclophosphamide with antiproliferative activities; increases the number of micronucleated polychromatic red blood cells isolated from mouse bone marrow at 40, 80, and 160 mg/kg; inhibits proliferation of isolated splenocytes in the allogenic mixed lymphocyte reaction at 100 mg/kg; reduces sheep red blood cell-induced increases in the number of antibody-producing spleen cells isolated from rats at 40 mg/kg